DILANTIN Suspension
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چکیده
Phenytoin is indicated for the control of generalized tonic-clonic (grand mal) and complex partial (psychomotor, temporal lobe) seizures and prevention and treatment of seizures occurring during or following neurosurgery. Phenytoin has also been used in the treatment of migraine, trigeminal neuralgia and certain psychoses. It has also been used in cardiac arrhythmias, digitalis intoxications, and post-event treatment of myocardial infarction.
منابع مشابه
Additivity of dilantin and vinblastine inhibitory effects on microtubule assembly.
Dilantin (phenytoin) is a commonly used antiepileptic agent that is known to decrease conductance of sodium and calcium ions and delay outward potassium currents. Separate from its antiseizure activity, dilantin interferes with microtubule protein polymerization. It induces metaphase arrest and potentiates the effects of the antimitotics vincristine and vinblastine in cell culture. We show here...
متن کاملMicellar Mediated Dissolution of a Hydantion Drug
Dissolution behaviour of both 5, 5-diphenyl hydantoin sodium commonly known as dilantin sodium (DS) and its corresponding marketed capsule dilantin have been studied in aqueous as well as micellar media. Percentage dissolution of both DS and its marketed capsule are found to be low as expected in aqueous medium due to its very low solubility in water. However, their dissolution tendency is foun...
متن کاملEffect of cortisol and age upon the dermal chemical response to dilantin.
Daily administration of sodium biphenyl hydantionate (Dilantin) to rats has been shown to increase markedly the dermal concentration of insoluble collagen and non-collagenous protein (1) as well as to decrease the concentration of both tissue water and fat (2). These effects were produced by ten or more daily doses of 100 mg of drug per kg body weight (3) and were a result of the specific struc...
متن کاملThe Resorption of Sodium Dilantin-produced Dermial
Dilantin has long been known to result in hyperplasia of the gingiva (1) and to increase the tensile strength of rat skin (2). We have shown that daily intraperitoneal injections of 25 mg of Dilantin resulted in marked increases in the insoluble collagen, hexosamine, and insoluble noncollagenous protein (scleroprotein) content of rat skin (3). Four daily doses of the drug were sufficient to sig...
متن کاملParenteral Dilantin® (Phenytoin Sodium Injection, USP) WARNING: CARDIOVASCULAR RISK ASSOCIATED WITH RAPID INFUSION
WARNING: CARDIOVASCULAR RISK ASSOCIATED WITH RAPID INFUSION The rate of intravenous Dilantin administration should not exceed 50 mg per minute in adults and 1-3 mg/kg/min (or 50 mg per minute, whichever is slower) in pediatric patients because of the risk of severe hypotension and cardiac arrhythmias. Careful cardiac monitoring is needed during and after administering intravenous Dilantin. Alth...
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تاریخ انتشار 2008